About Sernova, Corp. À propos de Sernova, Corp.
Sernova is committed to the development and clinical advancement of its products for metabolic, hematological and other chronic diseases using therapeutic cells transplanted into a patented implanted medical device, which forms an organ-like environment promoting long-term function and survival of the therapeutic cells. Sernova s'engage dans le développement et l'avancement clinique de ses produits contre les maladies métaboliques, hématologiques et autres maladies chroniques utilisant des cellules thérapeutiques transplantées dans un dispositif médical implanté breveté, qui forme un environnement semblable à un organe favorisant la fonction et la survie à long terme des cellules thérapeutiques.
The company’s management believes in building strong and long-lasting collaborations and partnerships that would lead to the rapid advancement of Sernova’s portfolio of products into the market, improving global health and bringing value to patients and society, in concert with our clinical development programs. La direction de la société croit à la mise en place de collaborations et de partenariats solides et durables qui permettraient au portefeuille de produits de Sernova de progresser rapidement sur le marché, d’améliorer la santé mondiale et d’apporter une valeur ajoutée aux patients et à la société, de concert avec nos programmes de développement clinique.
Indications: Les indications:
Diabetes Diabète
Haemophilia A Hémophilie A
Thyroid disease Maladie thyroïdienne
Clinical studies: Etudes cliniques:
Diabetes US phase I/II clinical study cleared by the FDA Etude clinique de phase I / II sur le diabète, approuvée par la FDA
First-in-human study in Diabetic subjects with hypoglycemia unawareness Première étude chez l'homme chez des sujets diabétiques peu conscients de l'hypoglycémie
Cell Pouch System™

Sernova’s Cell Pouch System™ is a novel implantable and scalable medical device which forms a highly vascularized organ-like environment in the body for the housing, function and long-term survival of therapeutic cells. These therapeutic cells release necessary proteins or hormones missing from the body to treat chronic diseases as an alternative to daily administration of drugs. Le Cell Pouch System™ est un nouveau dispositif médical préalablement implanté et formant un environnement naturel hautement vascularisé afin d’y loger des cellules thérapeutiques, favorisant leur bon fonctionnement et leur survie dans le corps. Ces cellules thérapeutiques libèrent les protéines ou les hormones nécessaires pour traiter les maladies chroniques comme alternative a l’administration quotidienne de médicaments.

Immune Protection Protection immunitaire

We have shown that cells can be protected using medications that prevent immune system attack within the Cell Pouch™. Nous avons montré que les cellules peuvent être protégées en utilisant des médicaments qui empêchent les attaques du système immunitaire dans la Cell Pouch™.
Microencapsulation technologies house cells within the Cell Pouch chambers and protect the cells from immune system attack. Les technologies de microencapsulation hébergent les cellules dans les chambres à cellules et les protègent des attaques du système immunitaire.
Technologies are in development to make transplanted cells unrecognizable to the immune system. Des technologies sont en cours de développement pour rendre les cellules greffées méconnaissables du système immunitaire.
Sernova’s Cell Pouch™, combined with immune protected therapeutic cells, offers protection from immune system attack creating an effective, safe, long-term and convenient therapeutic option for patients with chronic diseases who seek to improve their quality of life. Le Cell Pouch™ de Sernova, associé à des cellules immunitaires protégées, offre une protection contre le système immunitaire avec une option thérapeutique efficace, sûre, à long terme et pratique pour les patients atteints de maladies chroniques qui cherchent à améliorer leur qualité de vie.

Featured News Nouvelles en vedette
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Sernova Opens the Market Thursday, June 2, 2022
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Sernova Made the 2022 TSX Venture 50 List!
Canaccord Genuity Virtual MedTech, Diagnostics and Digital Health & Services Forum
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Dr. Tomei Conformal Coating Immunoprotection Webinar with Sernova
Sernova 2021 AGM Recording
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Sernova KOL Event on Thyroid Disease with Dr. Sam Wiseman
News Releases Communiqués de presse
Sernova to Participate in the Truist Securities Cell Therapy Symposium, Symposia-cel in June
Sernova Announces Positive Updated Phase 1/2 Clinical Data on Cell Pouch System™ at American Diabetes Association 82nd Scientific Sessions 2022
SERNOVA SHARES TO COMMENCE TRADING ON TSX ON JUNE 2, 2022
Sernova Receives Conditional Approval to Up-list to the Toronto Stock Exchange
Invest with Sernova Investir dans Sernova
If you are a shareholder, investor, broker, analyst, journalist, investment advisor, or looking to develop business opportunities, please feel free to contact us by email or telephone. Si vous êtes actionnaire, investisseur, courtier, analyste, journaliste, conseiller en placement ou souhaitez développer des opportunités d’affaires, n'hésitez pas à nous contacter par email ou par téléphone.
Sernova is a regenerative medicine company developing therapeutic technologies with multibillion-dollar market potential for each of its clinical indications. Sernova est une société de médecine régénérative développant des technologies thérapeutiques offrant un potentiel de marché de plusieurs milliards de dollars pour chacune de ses indications cliniques.
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Please read our Pour plus d’informations, veuillez lire notre Privacy policypolitique de confidentialité.
Sernova is a Collaborative Team Sernova, c’est aussi les collaborations
We believe in advancing our clinical programs and building strong and long-lasting collaborations and partnerships that will lead to the rapid advancement of Sernova’s portfolio of products into the market, improving global health and bringing value to patients and society. Nous croyons en la promotion de nos programmes cliniques et en la mise en place de collaborations et de partenariats solides et durables qui permettront au portefeuille de produits de Sernova de progresser rapidement sur le marché, d'améliorer la santé mondiale et d'apporter de la valeur aux patients et à la société.
Privacy PolicyPolitique de confidentialité
Updated July 6, 2018
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This Policy applies to all information gathered through the Website and/or any related marketing technique or events.
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Updates
This Policy is a living document and may be amended or updated from time to time without further notice. We encourage you to review the Policy periodically.
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If you have any questions or comments about our policy, you can email us at info@sernova.com or by phone at 1(877) 299-4603 or by mail at
Sernova Corp.
700 Collip Circle, Suite 114
London, ON Canada N6G 4X8
Mis à jour le 6 juillet 2018
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Sernova Corp.
700 Collip Circle, Suite 114
London, ON Canada N6G 4X8
Press Release Communiqué de presse - June 15, 2022 15 June, 2022
Sernova to Participate in the Truist Securities Cell Therapy Symposium, Symposia-cel in June
LONDON, Ontario – June 15, 2022 – Sernova Corp. (TSX:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, today announced that Dr. Philip Toleikis,
President & CEO of Sernova Corp., will be participating in the Truist Securities Cell Therapy Symposium,
Symposia-cel being held in person at the Lotte New York Palace on Tuesday, June 28, 2022. Company
management will also be participating in 1x1 meetings during the event.
Truist Securities Cell Therapy Symposium, Symposia-cel – June 28, 2022
Panel Title: Cell Therapy for Non-Oncology Indications
Date: Tuesday, June 28, 2022
Time: 2:00-3:00 PM ET
Presenter:
Dr. Philip Toleikis, President & CEO, Sernova Corp
Location: Lotte New York Palace*
* Further details available on the Truist event website
If you are interested in arranging a 1x1 meeting request, please contact your Truist representative.
ABOUT SERNOVA CORP. AND THE CELL POUCH SYSTEM™ PLATFORM FOR CELL THERAPY
Sernova Corp. is a clinical-stage biotechnology company that is developing regenerative medicine therapeutic
technologies for chronic diseases, including insulin-dependent diabetes, thyroid disease, and blood disorders
including hemophilia A. Sernova is currently focused on developing a ‘functional cure’ for insulin-dependent
diabetes with its lead asset, the Cell-Pouch System, a novel implantable and scalable medical device with
immune protected therapeutic cells. The Cell Pouch on implantation forms a natural vascularized tissue
environment in the body for long-term survival and function of therapeutic cells that release necessary proteins
or factors missing from the body to treat chronic diseases. Sernova’s Cell Pouch System has already shown it
can potentially provide a ‘functional cure’ to people with type 1 diabetes in an ongoing Phase I/II clinical study
at the University of Chicago. Sernova is also advancing a proprietary technology in collaboration with the
University of Miami to cloak the therapeutic cells from the immune system attack with the goal to eliminate the
need for chronic immunosuppressives. In May 2022, Sernova and Evotec entered into a global strategic
partnership to develop an implantable off-the-shelf iPSC-based (induced pluripotent stem cells) beta cell
replacement therapy. This partnership provides Sernova an unlimited supply of insulin-producing cells to treat
millions of patients with insulin-dependent diabetes (type 1 and type 2). Sernova is also gearing up to be in the
clinic in two additional programs that utilize its Cell Pouch System – an implantable cell therapy for benign
thyroid disease resulting from thyroid gland removal and an ex-vivo lentiviral factor 8 gene therapy for
hemophilia A.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Corporate:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
519-902-7923
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
212-915-2577
Media:
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
Press Release Communiqué de presse - June 06, 2022 6 June, 2022
Sernova Announces Positive Updated Phase 1/2 Clinical Data on Cell Pouch System™ at American Diabetes Association 82nd Scientific Sessions 2022
• Researchers from the Dr. Piotr Witkowski Laboratory at the University of Chicago presented updated data
on six patients with type 1 diabetes and hypoglycemia unawareness
• The first three patients have been insulin independent for over 2 years, 6 months, and 3 months,
respectively
• Those first three patients with islets transplanted into the Cell Pouch™ subsequently presented positive
serum C-peptide values confirming active insulin production by the Cell Pouch islet grafts
• The Cell Pouch was well tolerated with implant durations exceeding 35 months
LONDON, Ontario – June 6, 2022 – Sernova Corp. (TSX:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, today announced the presentation of
clinical data from its Phase 1/2 clinical trial supporting the potential of its proprietary Cell Pouch System to
provide a ‘functional cure’ for insulin-dependent diabetes. The updated data from the ongoing study being
conducted by Piotr Witkowski, M.D., Ph.D. at the University of Chicago, were presented as an oral podium
presentation at the American Diabetes Association (ADA) 82nd Scientific Sessions, held from June 3-7, 2022, at
the Ernest N. Morial Convention Center in New Orleans, LA.
The presented data, from the Dr. Piotr Witkowski Laboratory at the University of Chicago, reviewed the six
patients who lived with long-standing insulin-dependent type 1 diabetes (T1D) and hypoglycemia unawareness
prior to study treatment who underwent both Cell Pouch implantation and islet transplantation. Graft function
was measured by blood glucose, patient insulin usage, and C-peptide, a widely used measure of islet function.
The first three patients achieved complete and sustained insulin independence. Three additional patients on
study did not maintain optimal immunosuppression, which has now been resolved enabling those patients to
receive further protocol-defined islet transplants.
Key findings from interim clinical update:
• Surgical implantation of the Cell Pouch was found to be generally well tolerated with a favorable safety
profile
• All patients who had favorable immunosuppression achieved complete insulin independence
o The first three transplanted patients presented positive serum C-peptide values confirming active
insulin production after islet transplantation into the Sernova Cell Pouch
o Supplemental marginal dose islet transplantation via the portal vein was sufficient to allow those
three patients to achieve and maintain insulin independence for over 2 years, 6 months, and 3
months, respectively
o Insulin independent patients have HbA1c in the normal range: 5.0, 5.2, and 5.2%, respectively
• Dr. Witkowski further optimized outcomes in the ongoing clinical trial:
o Replacing patients’ own plasma with serum as the islet suspension medium
o Decreasing the concentration of islet suspensions transplanted to Cell Pouch resulted in greater
stimulated C-peptide
o The Cell Pouch implantation procedure was optimized with two shorter incisions to minimize
infection risk and enhance healing
o Implementing a higher capacity Cell Pouch System, that has been developed by Sernova, will
provide approximately 50% more volume to accommodate more islets at the optimal
concentration for use in future implantation procedures
“Despite some advances in the diabetes space, insulin-dependent diabetes patients continue to require
numerous injections daily, and for those with hypoglycemia unawareness, it can be increasingly life threatening.
We are committed to developing a ‘functional cure’ to potentially free patients from the life-limiting burdens of
this disease,” said Dr. Philip Toleikis, President and Chief Executive Officer of Sernova. “We are encouraged by
the data demonstrating our Cell Pouch System has been well tolerated and multiple patients remain insulin
independent. We remain on track to further dose the three aforementioned subjects and to implement the
higher capacity Cell Pouch System in the next implanted patients.”
The incidence of T1D in the U.S. (in ages 0 to 64 years) is estimated to be 64,000 cases annually, with a
predicted prevalence of 5 million people by 2050 (1,2). The annual direct cost of healthcare expenditures and
lost income from T1D has been estimated as $16 billion (3). Sernova’s Cell Pouch System is designed to
address this vastly expanding need by providing a ‘functional cure’ for the millions of people afflicted by
insulin-dependent diabetes worldwide. Sernova is also addressing the life-threatening complication of
hypoglycemia unawareness (HU) in patients with T1D. HU is a person’s inability to recognize the symptoms of
low blood sugar before it becomes severe enough to be incapacitating or even fatal. About 1 in 5 people with
T1D report experiencing hypoglycemia unawareness (4).
Dr. Piotr Witkowski, Director of Pancreatic Islet Transplantation Program at University of Chicago and study
Principal Investigator added, “The data coming out of the Cell Pouch and islet transplantation trial show
incredible promise for insulin-dependent diabetes patients. I am excited about the potential impact on the field
and look forward to seeing continued progression of the data from this trial.”
Sernova recently entered into a global strategic partnership with Evotec A.G., a Nasdaq listed biotechnology
company, to develop an implantable off-the-shelf induced pluripotent stem cell (iPSC) -based beta cell
replacement therapy, which will provide Sernova with an unlimited supply of insulin-producing cells,
circumventing any potential future islet supply issues. Sernova is also working to eliminate the need for chronic
immunosuppression with cell transplants by incorporating technology developed by Dr. Alice Tomei’s
laboratory at the University of Miami, to protect cells from immune system recognition.
For more information on the ongoing clinical study, go to clinicaltrials.gov (NCT03513939).
1. Rogers MAM, Kim C, Banerjee T, Lee JM. Fluctuations in the incidence of type 1 diabetes in the United
States from 2001 to 2015: a longitudinal study. BMC Med. 2017;15(1):199. Published 2017 Nov 8.
doi:10.1186/s12916-017-0958-6
2. Dabelea D, Mayer-Davis EJ, Saydah S, et al. Prevalence of type 1 and type 2 diabetes among children and
adolescents from 2001 to 2009. JAMA. 2014;311(17):1778-1786. doi:10.1001/jama.2014.3201
3. American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2017. Diabetes Care.
2018;41(5):917-928. doi:10.2337/dci18-0007
4. Reno CM, Litvin M, Clark AL, Fisher SJ. Defective counterregulation and hypoglycemia unawareness in
diabetes: mechanisms and emerging treatments. Endocrinol Metab Clin North Am. 2013;42(1):15-38.
doi:10.1016/j.ecl.2012.11.005
ABOUT SERNOVA CORP. AND THE CELL POUCH SYSTEM PLATFORM FOR CELL THERAPY
Sernova Corp is a clinical-stage biotechnology company that is developing regenerative medicine therapeutic
technologies for chronic diseases, including insulin-dependent diabetes, thyroid disease, and blood disorders
like hemophilia A. Sernova is currently focused on finding a ‘functional cure’ for insulin-dependent diabetes
with its lead asset, the Cell-Pouch SystemTM, a novel implantable and scalable medical device which forms a
natural environment in the body for long-term survival and function of therapeutic cells that release necessary
proteins or factors missing from the body to treat chronic diseases. Sernova’s Cell Pouch System has already
shown it can potentially provide a ‘functional cure’ to people with type 1 diabetes in an ongoing Phase I/II study
at the University of Chicago. Sernova is also working on technology with the University of Miami to cloak the
implant from the immune system, to eliminate the need for immunosuppressives to protect the cells from
immune system attack. In May 2022, Sernova and Evotec entered into a global strategic partnership to develop
an implantable off-the-shelf iPSC-based (induced pluripotent stem cells) beta cell replacement therapy. This
partnership provides Sernova an unlimited supply of insulin-producing cells to treat millions of patients with
insulin-dependent diabetes (type 1 and type 2). Sernova is also gearing up to be in the clinic in two programs
that utilize its Cell Pouch System – an implantable cell therapy for benign thyroid disease resulting from thyroid
gland removal and an ex-vivo lentiviral factor 8 gene therapy for hemophilia A.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Corporate:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should"
occur are used to identify forward-looking statements. These statements reflect management’s beliefs with
respect to future events and are based on information currently available to management on the date such
statements were made. Many factors could cause Sernova’s actual results, performances or achievements to
not be as anticipated, estimated or intended or to differ materially from those expressed or implied by the
forward-looking statements contained in this news release. Such factors could include, but are not limited to,
the company’s ability to secure additional financing and licensing arrangements on reasonable terms, or at all;
ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch System and/or
related technologies, including the timing and results of those trials; ability to obtain all necessary regulatory
approvals, or on a timely basis; ability to in-license additional complementary technologies; ability to execute
its business strategy and successfully compete in the market; and the inherent risks associated with the
development of biotechnology combination products generally. Many of the factors are beyond our control,
including those caused by, related to, or impacted by the novel coronavirus pandemic. Investors should consult
the company’s quarterly and annual filings available on www.sedar.com for additional information on risks and
uncertainties relating to the forward-looking statements. Sernova expressly disclaims any intention or
obligation to update or revise any forward-looking statements, whether as a result of new information, future
events or otherwise.
Press Release Communiqué de presse - June 01, 2022 1 June, 2022
SERNOVA SHARES TO COMMENCE TRADING ON TSX ON JUNE 2, 2022
June 1, 2022 6:00 a.m. EDT
London, Ontario – June 1, 2022 – Sernova Corp. (TSX-V:SVA; OTCQB:SEOVF; FSE/XETRA:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that its common
shares have been approved for listing on the Toronto Stock Exchange (the "TSX") and will commence trading
on the TSX at the opening of market on June 2, 2022. Concurrent with the TSX listing, the common shares of
the Company will be delisted from the TSX Venture Exchange.
Shareholders are not required to exchange their share certificates or take any other action in connection with
the TSX listing, as there will be no change in the trading symbol or CUSIP for the common shares. The
Company will continue to trade its common shares on the OTCQB market in the United States under the
symbol "SEOVF", and the Frankfurt exchange under the symbol "PSH".
ABOUT SERNOVA CORP. AND THE CELL POUCH SYSTEM™ PLATFORM FOR CELL THERAPY
Sernova Corp. is developing regenerative medicine therapeutic technologies using a medical device and
immune protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived
cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-
dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of
proteins or hormones missing or in short supply within the body.
The Cell Pouch™ is a proprietary, scalable, implantable macro- encapsulation device solution designed for the
long-term survival and function of therapeutic cells. After implantation, the device incorporates with tissue,
forming highly vascularized, native tissue chambers for the transplantation and function of therapeutic cells,
that release proteins and hormones as required to treat disease.
The Cell Pouch along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
For more information, please visit www.sernova.com
For further information contact:
Corporate and Investors:
Sernova Corp.
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, MD
LifeSci Communications
emiller@lifescicomms.com
Neither the TSXV nor the TSX accepts responsibility for the adequacy or accuracy of this news release.
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of
future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials, and the development of new technologies, cell therapy solutions and or products. The information
disclosed represents results from one patient and may not be representative of all study patients or of the final
study results. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking
statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - May 24, 2022 24 May, 2022
Sernova Receives Conditional Approval to Up-list to the Toronto Stock Exchange
London, Ontario – May 24, 2022 – Sernova Corp. (TSX-V:SVA; OTCQB:SEOVF; FSE/XETRA:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that it has
received conditional approval to list its common shares on the Toronto Stock Exchange (the "TSX") and move
off of the TSX Venture Exchange ("TSXV").
Final approval of the listing is subject to the Company meeting certain customary conditions required by the
TSX. The company will issue a press release once the TSX confirms the date when trading of Sernova’s
common shares is expected to commence on the TSX. Upon completion of the final listing requirements,
Sernova’s common shares will be delisted from the TSXV.
Dr. Philip Toleikis, President and CEO of Sernova Corp commented, “Moving onto the Toronto Stock Exchange
represents a milestone achievement in our evolution as an emerging regenerative medicine company. Up-
listing will provide enhanced liquidity and bring new visibility and investors into the company as we advance
our therapeutic cell therapy platform with the goal to provide ‘functional cures’ for multiple diseases including
type one diabetes, hemophilia and thyroid disease.”
Shareholders are not required to exchange their share certificates or take any other action in connection with
the TSX listing, as there will be no change in the trading symbol or CUSIP for the common shares. The
Company will continue to trade its common shares on the OTCQB market in the United States under the
symbol "SEOVF", and the Frankfurt exchange under the symbol "PSH".
ABOUT SERNOVA CORP. AND THE CELL POUCH SYSTEM™ PLATFORM FOR CELL THERAPY
Sernova Corp. is developing regenerative medicine therapeutic technologies using a medical device and
immune protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived
cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-
dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of
proteins or hormones missing or in short supply within the body.
The Cell Pouch™ is a proprietary, scalable, implantable macro- encapsulation device solution designed for the
long-term survival and function of therapeutic cells. After implantation, the device incorporates with tissue,
forming highly vascularized, native tissue chambers for the transplantation and function of therapeutic cells,
that release proteins and hormones as required to treat disease.
The Cell Pouch along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
For more information, please visit www.sernova.com
For further information contact:
Corporate and Investors:
Sernova Corp.
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, MD
LifeSci Communications
emiller@lifescicomms.com
Neither the TSXV nor the TSX accepts responsibility for the adequacy or accuracy of this news release.
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of
future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials, and the development of new technologies, cell therapy solutions and or products. The information
disclosed represents results from one patient and may not be representative of all study patients or of the final
study results. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking
statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - May 17, 2022 17 May, 2022
Sernova and Evotec Enter into an Exclusive Global Strategic Partnership for iPSC-Based Beta Cell Replacement Therapy to Develop and Commercialize a 'Functional Cure' for Diabetes
• Partnership Leverages Sernova’s Proprietary Cell Pouch System™ with Evotec’s iPSC-Based Insulin-
Producing Beta Cells
• Partners to Develop and Commercialize an Off-The-Shelf Cell Replacement Therapy for Treatment of
Patients with Insulin-Dependent Diabetes
• Evotec to Make Strategic Equity Investment of CAD $27 M / €20 M in Sernova
• Sernova / Evotec Joint Conference Call and Webcast at 8:30 am EDT May 17, 2022
LONDON, ONTARIO – May 17, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE/XETRA:PSH), a
clinical-stage company and leader in regenerative medicine cell therapeutics, and Evotec SE (FSE: EVT;
NASDAQ: EVO), a global pharmaceutical and life science company, and leading developer of iPSC cell
technologies for therapeutic applications, are pleased to announce an exclusive global strategic partnership to
develop a best-in-class cell therapy treatment for people living with insulin-dependent diabetes. The two
Companies will combine and leverage their respective technologies and scientific expertise to develop an
implantable iPSC-based (induced pluripotent stem cells) beta cell replacement therapy to provide an unlimited
insulin-producing cell source to treat patients with insulin-dependent diabetes.
The collaboration agreement is a transformative partnership that combines Sernova’s Cell Pouch System
technologies, which has demonstrated Phase 1/2 clinical proof-of-concept using human donor islets, with
Evotec’s iPSC-based beta cells. Incorporating Evotec’s insulin-producing, ethically-derived beta cells within
Sernova’s Cell Pouch platform creates the potential to provide a ‘functional cure’ for millions of people
suffering from diabetes using a cGMP controlled and scalable off-the-shelf product.
With its long-standing beta cell development program, Evotec has demonstrated the ability to reliably
produce an unlimited supply of high quality, stable, human iPSC-derived beta cells using its proprietary
process for producing islet-like clusters in a quality-controlled scalable bioreactor process. These islet-like
clusters have now been proven to be functionally equivalent to primary human islets in their ability to
normalize blood glucose using in vivo models of type 1 diabetes (T1D).
The partnership provides Sernova a global exclusive option to license Evotec’s iPSC-based beta cells for use in
treating both type 1 and type 2 diabetes. In addition to entering into the collaboration agreement, Evotec has
made a strategic equity investment of €15M and will make a further investment of €5M. Specifically,
concurrently with the entering into the collaboration agreement, Evotec acquired a total of 12,944,904
common shares at a price of CAD $1.57 per share for gross proceeds to Sernova of $20,323,500. In addition,
pursuant to an unconditional purchase warrant, Evotec will acquire, on or before August 31, 2022, a further
2,709,800 common shares at a price of CAD$2.50 per share for gross proceeds of $6,774,500. All of the
securities issued to Evotec are subject to a four month hold period.
Further to the collaboration and Evotec’s strategic equity investment, Dr. Cord Dohrmann, Chief Scientific
Officer of Evotec will join Sernova’s Board of Directors.
Dr. Philip Toleikis, President, and Chief Executive Officer of Sernova, commented, “In tandem with our current
clinical islet cell program, Sernova entered into multiple pharmaceutical research collaborations to identify the
highest quality and most compatible iPSC cell technology, and validate the cells preclinically within our Cell
Pouch System. Evotec is an iPSC powerhouse having dedicated many years and substantial resources to
developing high quality and stable stem cell technologies for multiple therapeutic applications. In every sense,
both as a global strategic partner and as an iPSC expert, Evotec has exceeded all our expectations and Dr.
Dohrmann’s appointment to Sernova’s Board adds significant regenerative medicine depth and cell therapy
expertise. Today’s announcement of this joint iPSC beta-cell partnership completes the three pillars of our
diabetes cell therapy platform. Alongside our clinically validated Cell Pouch System and recently acquired
conformal coating immune protection technology, this now establishes a total regenerative medicine cell
therapy solution for insulin-dependent diabetes.”
Dr Cord Dohrmann, Chief Scientific Officer of Evotec, commented, “We searched long and hard for the right
partner. Sernova clearly ticks all boxes with their clinically validated Cell Pouch™ technology, which fits
perfectly to Evotec’s iPSC-based beta cells. Together we will progress a highly differentiated first-in-class beta
cell therapy into clinical development with the common goal to bring a truly transformative therapy to insulin-
dependent diabetic patients. The synergies of Evotec’s and Sernova’s technologies puts Sernova in position to
become the world’s leader in beta cell replacement therapy. Our equity investment underlines our strategic
interest in this collaboration with Sernova. I am very much looking forward to collaborating with Sernova on
the project as well as contributing to their Board of Directors.”
Sernova has acquired an option for an exclusive global license to Evotec’s Induced Pluripotent Stem Cell
(iPSC)-based Beta cells to treat patients with insulin-dependent diabetes. From an operational perspective,
the preclinical development program(s) will be jointly funded by Sernova and Evotec until IND acceptance.
Sernova has the right to exercise its option for an exclusive global license upon IND filing. Evotec will
contribute its cell manufacturing capabilities through research, development and product commercialization
and will decide in the future on the joint funding of clinical development. Upon commercialization, there will
be a profit-sharing arrangement between the two companies, with the split being dependent on Evotec’s
participation in funding the clinical development program.
Joint Sernova / Evotec Conference Call and Webcast Details:
Date: Tuesday, May 17, 2022
Time: 8:30 am EDT
US Toll Free: 1-877-704-4453
International: 1-201-389-0920
Conference ID: 13730121
Webcast: https://viavid.webcasts.com/starthere.jsp?ei=1550130&tp_key=3de87cce1d
A simultaneous slide presentation will be available via the above webcast link.
ABOUT SERNOVA CORP AND THE CELL POUCH SYSTEM CELL THERAPY PLATFORM
Sernova Corp is developing regenerative medicine therapeutic technologies using a medical device and
immune protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived
cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-
dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of
proteins or hormones missing or in short supply within the body.
The Cell Pouch, as part of the Cell Pouch System, is a proprietary, scalable, implantable macro- encapsulation
device solution designed for the long-term survival and function of therapeutic cells. After implantation, the
device incorporates with tissue, forming highly vascularized, native tissue chambers for the transplantation
and function of therapeutic cells, that release proteins and hormones as required to treat disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
For more information, please visit www.sernova.com
ABOUT EVOTEC AND iPSC
Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be
generated directly from adult cells. The iPSC technology was pioneered by Shinya Yamanaka’s lab in Kyoto,
Japan, who showed in 2006 that the introduction of four specific genes encoding transcription factors could
convert adult cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John
Gurdon “for the discovery that mature cells can be reprogrammed to become pluripotent”. Pluripotent stem
cells hold great promise in the field of regenerative medicine. Because they can propagate indefinitely, as well
as give rise to every other cell type in the body (such as neurons, heart, pancreatic and liver cells), they
represent a single source of cells that could be used to replace those lost to damage or disease.
Evotec has built an industrialised iPSC infrastructure that represents one of the largest and most sophisticated
iPSC platforms in the industry. Evotec’s iPSC platform has been developed over the last years with the goal to
industrialise iPSC-based drug screening in terms of throughput, reproducibility and robustness to reach the
highest industrial standards, and to use iPSC-based cells in cell therapy approaches via the Company’s
proprietary EVOcells platform.
For further information contact:
Corporate and Investors:
Sernova Corp
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, MD
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees
of future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials, and the development of new technologies, cell therapy solutions and or products. The information
disclosed represents results from one patient and may not be representative of all study patients or of the final
study results. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking
statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - May 09, 2022 9 May, 2022
Sernova Announces Abstract on Phase 1/2 Trial with Cell Pouch Selected for Oral Podium Presentation at American Diabetes Association 82nd Scientific Sessions 2022
LONDON, ONTARIO – May 9, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical-stage cell therapy therapeutics company focused on developing a potential ‘functional cure’ for type 1
diabetes (T1D) and other chronic diseases, is pleased to announce that that an abstract has been selected for
an oral podium presentation at the upcoming American Diabetes Association (ADA) 82nd Scientific Sessions, to
be held from June 3-7, 2022, at the Ernest N. Morial Convention Center in New Orleans, LA.
Abstract 306-OR: Modified Approach for Improved Islet Allotransplantation into Prevascularized Sernova Cell
PouchTM Device: Preliminary Results of the Phase I/II Clinical Trial at University of Chicago
Abstract Session: Islet Transplantation —Basic Science
Session Date/Time: Monday, June 6, 2022 at 2:15 PM – 4:15 PM CT
Presentation Time: 3:15-3:30 PM CT
Authors: Bachul PJ, Perez-Guetierrez A, Ling-jia Wang, Golab K, Basto L, Perea L, Tibudan M, Braden J,
Thomas C, Philipson L, Barth R, Fung JJ, Witkowski P
Sernova will disclose additional information about the presentation at the time of the conference in alignment
with the American Diabetes Association’s abstract embargo policies.
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Corporate:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Press Release Communiqué de presse - May 05, 2022 5 May, 2022
Sernova to Participate in Multiple U.S. Healthcare Investor Conferences
Sernova Engages Leading U.S.-Based Healthcare Communications Firm to Broaden Awareness of Potential
‘Functional Cure’ Technology for Type 1 Diabetes
LONDON, ONTARIO – May 5, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical stage regenerative medicine company focused on developing a potential ‘functional cure’ for type 1
diabetes (T1D) and other chronic diseases including hemophilia A and thyroid disease, today announced that
the company will be participating in several upcoming U.S. healthcare industry and investor conferences.
Conference details are provided below.
The Company is also pleased to announce it has engaged New York-based LifeSci Communications, a global
life science and medical technologies-focused communications and marketing agency. LifeSci Communications
will assist Sernova to expand and elevate its profile through strategic communications and public relations.
Sernova is also working with affiliate LifeSci Advisors LLC, a leading investor relations consultancy firm serving
life science companies, providing institutional investor communications and capital markets outreach services
in support of the Company’s U.S. capital markets objectives.
“With multiple collaborations advancing across our pipeline and growing interest in our best-in-class cell
therapy therapeutic solution platform - consisting of immune protected therapeutic cells and our proprietary
Cell Pouch™ medical device - as a potential ‘functional cure’ for multiple patient populations, the timing is right
to drive awareness of our unique cell therapy proposition and unprecedented clinical results including the
demonstration of continuous insulin independence for over two years now in our most advanced Phase 1/2
T1D study patient, in contrast to the clinical setbacks of several of our peer companies,” commented Dr.
Philip Toleikis, President & CEO of Sernova.
UPCOMING U.S. HEALTHCARE INDUSTRY AND INSTITUTIONAL INVESTOR PRESENTATIONS
Event: Roth Capital’s Canada Corporate Access Day
Date: May 17, 2022
Format: Corporate presentation and 1x1 meetings with institutional investors
Location: New York, NY
Event: H.C. Wainwright Global Life Sciences Conference
Date: May 24-25, 2022
Format: Corporate presentation and 1x1 meetings with institutional investors
Location: Miami Beach, FL
Event: Truist Securities Cell Therapy Symposium
Date: June 28, 2022
Format: Panel expert and discussions
Location: New York, NY
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Investors and Analysts
Christopher Barnes Corey Davis, Ph.D.
VP, Investor Relations Managing Director
Sernova Corp. LifeSci Advisors, LLC
christopher.barnes@sernova.com cdavis@lifesciadvisors.com
Tel: 519-902-7923 Tel: 212-915-2577
www.sernova.com
Media
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to complete collaboration activities; ability to secure collaboration arrangements from its
collaboration activities; ability to execute its business strategy and successfully compete in the market; and
the inherent risks associated with the development of biotechnology combination products generally. Many of
the factors are beyond our control, including those caused by, related to, or impacted by the novel coronavirus
pandemic. Investors should consult the company’s quarterly and annual filings available on www.sedar.com
for additional information on risks and uncertainties relating to the forward-looking statements. Sernova
expressly disclaims any intention or obligation to update or revise any forward-looking statements, whether as
a result of new information, future events or otherwise.
Press Release Communiqué de presse - April 29, 2022 29 April, 2022
Sernova Announces 2022 Annual General Meeting Results
LONDON, ONTARIO – April 29, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE:PSH), a clinical stage
regenerative medicine company focused on developing a potential ‘functional cure’ for type 1 diabetes (T1D)
and other chronic diseases, is pleased to announce results from its Annual General Meeting of Shareholders
(the “AGM”) held virtually via live audio webcast, on April 28, 2022. Shareholders voted overwhelmingly in
favour of all management resolutions proposed in the Company’s Information Circular.
The following resolutions were proposed and approved at the AGM:
• The re-election of the following directors for the ensuing year: Frank Holler, James Parsons, Jeffrey
Bacha, Deborah Brown, Dr. Mohammad Azab and Dr. Philip Toleikis.
• The appointment of Davidson & Company LLP, as auditors of the Company until the next annual meeting
and the authorization of the directors of the Company to fix the remuneration to be paid to the auditors.
“I sincerely appreciate our shareholders ongoing support for Sernova. The Board and management are very
excited about the immediate and long-term prospects of the Company as we expand our therapeutic
applications, broaden our capital markets following and execute on a number of strategic initiatives,” said Dr.
Philip Toleikis, President & CEO of Sernova Corp.
Management’s corporate update to shareholders will be available on Sernova’s website next week at
www.sernova.com.
For further information contact:
Sernova Corp
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
ABOUT SERNOVA
Sernova is developing regenerative medicine therapeutic technologies using a medical device and immune
protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived cells) to
improve the treatment and quality of life of people with chronic metabolic diseases such as insulin- dependent
diabetes, blood disorders including hemophilia, and other diseases treated through replacement of proteins or
hormones missing or in short supply within the body. For more information, please visit www.sernova.com
ABOUT SERNOVA’S CELL POUCH
The Cell Pouch is a novel, proprietary, scalable, implantable macro-encapsulation device designed for the
long- term survival and function of therapeutic cells. The device is designed to incorporate with tissue, forming
highly vascularized tissue chambers for the transplantation and function of therapeutic cells which then
release proteins and hormones as required to treat disease. The device along with therapeutic cells has been
shown to provide long-term safety and efficacy in small and large animal models of diabetes and has been
proven to provide a biologically compatible environment for insulin-producing cells in humans.
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees
of future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials. The information disclosed represents results from one patient and may not be representative of all
study patients or of the final study results. Sernova expressly disclaims any intention or obligation to update or
revise any forward-looking statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - March 17, 2022 17 March, 2022
Data Safety Monitoring Board Recommends Continuation of Phase 1/2 Clinical Trial with Sernova’s Cell Pouch System™ in Patients with Type-1 Diabetes
Confirms Ongoing Safety and Tolerability of Sernova’s Cell Pouch
March 17, 2022 10:00 a.m. EDT
LONDON, ONTARIO – March 17, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that the Data
Safety Monitoring Board ("DSMB") has completed the third annual review of Sernova’s ongoing Phase 1/2
clinical study “Safety, Tolerability and Efficacy Study of Sernova’s Cell Pouch for Clinical Islet Transplantation”
in patients with Type-1 Diabetes (T1D) who suffer from hypoglycemia unawareness and severe hypoglycemic
events.
In their assessment, the DSMB recommended that the clinical study should continue according to the study
plan.
The DSMB is an independent committee of clinical experts who review the accumulated trial data to evaluate
patient safety and ensure the integrity of the study data.
“This recommendation from the DSMB affirms our understanding of the safety of Cell Pouch in this patient
population transplanted with human donor islets. We look forward to sharing updates from the study through
upcoming conference presentations by Dr. Piotr Witkowski, the trial Principal Investigator.” said Dr. Philip
Toleikis, President & CEO of Sernova Corp.
For more information on this clinical trial, please visit www.clinicaltrials.gov/ct2/show/NCT03513939. For
more information on enrollment and recruitment details please visit www.pwitkowski.org/sernova.
ABOUT HYPOGLYCEMIA UNAWARENESS
Hypoglycemia unawareness is a person’s inability to recognize the symptoms of low blood sugar before they
become severe enough to be incapacitating or even fatal, which may occur when blood glucose levels are
below 3.0 mmol/L. It is estimated that approximately 15% of people with T1D, or approximately 240,000
people, are affected by hypoglycemia unawareness in the US alone.
Severe symptoms of low blood sugar include confusion, slurred speech, impaired motor coordination and
personality changes. Individuals experiencing a severe hypoglycemic event can lose their ability for self-care
and self-control, requiring urgent intervention from another person to prevent loss of consciousness, seizure,
coma, or death. After a person has had a first hypoglycemia unawareness episode, more are likely to occur.
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Positive initial results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Press Release Communiqué de presse - February 24, 2022 24 February, 2022
Sernova Corp Ranks Among Top 50 Performing Companies on the 2022 TSX Venture List
Sernova awarded top performer status for two years standing
February 24, 2022 7:30 a.m. EST
LONDON, ONTARIO – February 24, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical-stage regenerative medicine and cell therapy therapeutics company focused on developing a potential
‘functional cure’ for type 1 diabetes (T1D) and other chronic diseases, is pleased to announce that that it has
been named as one of the top 50 performers on the TSX Venture Exchange.
The 2022 TSX Venture Top 50 is a ranking of top performers on the TSX Venture Exchange over the last year
based on three equally weighted criteria: share price appreciation, average trading volume and market
capitalization growth.
“We are honored by the TSX Venture Exchange recognition of Sernova as a 2022 Top 50 recipient company.
Being awarded this title two years in a row is strong validation of our persistent dedication to increasing
shareholder value as we continue to deliver on our strategic plan to build a leadership position in the
regenerative medicine cell therapy therapeutics field. In 2022, we look forward to driving continued success
through, evolving our clinical programs, further developing our pharmaceutical partnerships and by advancing
our capital market initiatives,” said Dr. Philip Toleikis, Chief Executive Officer of Sernova.
As part of the award, the TSX Venture Exchange sponsored a Q&A highlight interview with Dr. Toleikis. To view
the video, please https://share.vidyard.com/watch/dsfSgoQyYi87x8pj8oUEz6
and for the complete list of 2022 TSX Venture 50 companies.
ABOUT SERNOVA
Sernova is developing regenerative medicine therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. The device
upon implantation is designed to incorporate with tissue, forming highly vascularized tissue chambers for the
transplantation and function of therapeutic cells, which then release proteins and hormones as required to
treat disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
I/II study at the University of Chicago. Positive initial results have been presented at several international
scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.