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Press Release Communiqué de presse - May 24, 2022 24 May, 2022
Sernova Receives Conditional Approval to Up-list to the Toronto Stock Exchange
London, Ontario – May 24, 2022 – Sernova Corp. (TSX-V:SVA; OTCQB:SEOVF; FSE/XETRA:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that it has
received conditional approval to list its common shares on the Toronto Stock Exchange (the "TSX") and move
off of the TSX Venture Exchange ("TSXV").
Final approval of the listing is subject to the Company meeting certain customary conditions required by the
TSX. The company will issue a press release once the TSX confirms the date when trading of Sernova’s
common shares is expected to commence on the TSX. Upon completion of the final listing requirements,
Sernova’s common shares will be delisted from the TSXV.
Dr. Philip Toleikis, President and CEO of Sernova Corp commented, “Moving onto the Toronto Stock Exchange
represents a milestone achievement in our evolution as an emerging regenerative medicine company. Up-
listing will provide enhanced liquidity and bring new visibility and investors into the company as we advance
our therapeutic cell therapy platform with the goal to provide ‘functional cures’ for multiple diseases including
type one diabetes, hemophilia and thyroid disease.”
Shareholders are not required to exchange their share certificates or take any other action in connection with
the TSX listing, as there will be no change in the trading symbol or CUSIP for the common shares. The
Company will continue to trade its common shares on the OTCQB market in the United States under the
symbol "SEOVF", and the Frankfurt exchange under the symbol "PSH".
ABOUT SERNOVA CORP. AND THE CELL POUCH SYSTEM™ PLATFORM FOR CELL THERAPY
Sernova Corp. is developing regenerative medicine therapeutic technologies using a medical device and
immune protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived
cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-
dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of
proteins or hormones missing or in short supply within the body.
The Cell Pouch™ is a proprietary, scalable, implantable macro- encapsulation device solution designed for the
long-term survival and function of therapeutic cells. After implantation, the device incorporates with tissue,
forming highly vascularized, native tissue chambers for the transplantation and function of therapeutic cells,
that release proteins and hormones as required to treat disease.
The Cell Pouch along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
For more information, please visit www.sernova.com
For further information contact:
Corporate and Investors:
Sernova Corp.
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, MD
LifeSci Communications
emiller@lifescicomms.com
Neither the TSXV nor the TSX accepts responsibility for the adequacy or accuracy of this news release.
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of
future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials, and the development of new technologies, cell therapy solutions and or products. The information
disclosed represents results from one patient and may not be representative of all study patients or of the final
study results. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking
statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - May 17, 2022 17 May, 2022
Sernova and Evotec Enter into an Exclusive Global Strategic Partnership for iPSC-Based Beta Cell Replacement Therapy to Develop and Commercialize a ‘Functional Cure’ for Diabetes
• Partnership Leverages Sernova’s Proprietary Cell Pouch System™ with Evotec’s iPSC-Based Insulin-
Producing Beta Cells
• Partners to Develop and Commercialize an Off-The-Shelf Cell Replacement Therapy for Treatment of
Patients with Insulin-Dependent Diabetes
• Evotec to Make Strategic Equity Investment of CAD $27 M / €20 M in Sernova
• Sernova / Evotec Joint Conference Call and Webcast at 8:30 am EDT May 17, 2022
LONDON, ONTARIO – May 17, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE/XETRA:PSH), a
clinical-stage company and leader in regenerative medicine cell therapeutics, and Evotec SE (FSE: EVT;
NASDAQ: EVO), a global pharmaceutical and life science company, and leading developer of iPSC cell
technologies for therapeutic applications, are pleased to announce an exclusive global strategic partnership to
develop a best-in-class cell therapy treatment for people living with insulin-dependent diabetes. The two
Companies will combine and leverage their respective technologies and scientific expertise to develop an
implantable iPSC-based (induced pluripotent stem cells) beta cell replacement therapy to provide an unlimited
insulin-producing cell source to treat patients with insulin-dependent diabetes.
The collaboration agreement is a transformative partnership that combines Sernova’s Cell Pouch System
technologies, which has demonstrated Phase 1/2 clinical proof-of-concept using human donor islets, with
Evotec’s iPSC-based beta cells. Incorporating Evotec’s insulin-producing, ethically-derived beta cells within
Sernova’s Cell Pouch platform creates the potential to provide a ‘functional cure’ for millions of people
suffering from diabetes using a cGMP controlled and scalable off-the-shelf product.
With its long-standing beta cell development program, Evotec has demonstrated the ability to reliably
produce an unlimited supply of high quality, stable, human iPSC-derived beta cells using its proprietary
process for producing islet-like clusters in a quality-controlled scalable bioreactor process. These islet-like
clusters have now been proven to be functionally equivalent to primary human islets in their ability to
normalize blood glucose using in vivo models of type 1 diabetes (T1D).
The partnership provides Sernova a global exclusive option to license Evotec’s iPSC-based beta cells for use in
treating both type 1 and type 2 diabetes. In addition to entering into the collaboration agreement, Evotec has
made a strategic equity investment of €15M and will make a further investment of €5M. Specifically,
concurrently with the entering into the collaboration agreement, Evotec acquired a total of 12,944,904
common shares at a price of CAD $1.57 per share for gross proceeds to Sernova of $20,323,500. In addition,
pursuant to an unconditional purchase warrant, Evotec will acquire, on or before August 31, 2022, a further
2,709,800 common shares at a price of CAD$2.50 per share for gross proceeds of $6,774,500. All of the
securities issued to Evotec are subject to a four month hold period.
Further to the collaboration and Evotec’s strategic equity investment, Dr. Cord Dohrmann, Chief Scientific
Officer of Evotec will join Sernova’s Board of Directors.
Dr. Philip Toleikis, President, and Chief Executive Officer of Sernova, commented, “In tandem with our current
clinical islet cell program, Sernova entered into multiple pharmaceutical research collaborations to identify the
highest quality and most compatible iPSC cell technology, and validate the cells preclinically within our Cell
Pouch System. Evotec is an iPSC powerhouse having dedicated many years and substantial resources to
developing high quality and stable stem cell technologies for multiple therapeutic applications. In every sense,
both as a global strategic partner and as an iPSC expert, Evotec has exceeded all our expectations and Dr.
Dohrmann’s appointment to Sernova’s Board adds significant regenerative medicine depth and cell therapy
expertise. Today’s announcement of this joint iPSC beta-cell partnership completes the three pillars of our
diabetes cell therapy platform. Alongside our clinically validated Cell Pouch System and recently acquired
conformal coating immune protection technology, this now establishes a total regenerative medicine cell
therapy solution for insulin-dependent diabetes.”
Dr Cord Dohrmann, Chief Scientific Officer of Evotec, commented, “We searched long and hard for the right
partner. Sernova clearly ticks all boxes with their clinically validated Cell Pouch™ technology, which fits
perfectly to Evotec’s iPSC-based beta cells. Together we will progress a highly differentiated first-in-class beta
cell therapy into clinical development with the common goal to bring a truly transformative therapy to insulin-
dependent diabetic patients. The synergies of Evotec’s and Sernova’s technologies puts Sernova in position to
become the world’s leader in beta cell replacement therapy. Our equity investment underlines our strategic
interest in this collaboration with Sernova. I am very much looking forward to collaborating with Sernova on
the project as well as contributing to their Board of Directors.”
Sernova has acquired an option for an exclusive global license to Evotec’s Induced Pluripotent Stem Cell
(iPSC)-based Beta cells to treat patients with insulin-dependent diabetes. From an operational perspective,
the preclinical development program(s) will be jointly funded by Sernova and Evotec until IND acceptance.
Sernova has the right to exercise its option for an exclusive global license upon IND filing. Evotec will
contribute its cell manufacturing capabilities through research, development and product commercialization
and will decide in the future on the joint funding of clinical development. Upon commercialization, there will
be a profit-sharing arrangement between the two companies, with the split being dependent on Evotec’s
participation in funding the clinical development program.
Joint Sernova / Evotec Conference Call and Webcast Details:
Date: Tuesday, May 17, 2022
Time: 8:30 am EDT
US Toll Free: 1-877-704-4453
International: 1-201-389-0920
Conference ID: 13730121
Webcast: https://viavid.webcasts.com/starthere.jsp?ei=1550130&tp_key=3de87cce1d
A simultaneous slide presentation will be available via the above webcast link.
ABOUT SERNOVA CORP AND THE CELL POUCH SYSTEM CELL THERAPY PLATFORM
Sernova Corp is developing regenerative medicine therapeutic technologies using a medical device and
immune protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived
cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-
dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of
proteins or hormones missing or in short supply within the body.
The Cell Pouch, as part of the Cell Pouch System, is a proprietary, scalable, implantable macro- encapsulation
device solution designed for the long-term survival and function of therapeutic cells. After implantation, the
device incorporates with tissue, forming highly vascularized, native tissue chambers for the transplantation
and function of therapeutic cells, that release proteins and hormones as required to treat disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
For more information, please visit www.sernova.com
ABOUT EVOTEC AND iPSC
Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be
generated directly from adult cells. The iPSC technology was pioneered by Shinya Yamanaka’s lab in Kyoto,
Japan, who showed in 2006 that the introduction of four specific genes encoding transcription factors could
convert adult cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John
Gurdon “for the discovery that mature cells can be reprogrammed to become pluripotent”. Pluripotent stem
cells hold great promise in the field of regenerative medicine. Because they can propagate indefinitely, as well
as give rise to every other cell type in the body (such as neurons, heart, pancreatic and liver cells), they
represent a single source of cells that could be used to replace those lost to damage or disease.
Evotec has built an industrialised iPSC infrastructure that represents one of the largest and most sophisticated
iPSC platforms in the industry. Evotec’s iPSC platform has been developed over the last years with the goal to
industrialise iPSC-based drug screening in terms of throughput, reproducibility and robustness to reach the
highest industrial standards, and to use iPSC-based cells in cell therapy approaches via the Company’s
proprietary EVOcells platform.
For further information contact:
Corporate and Investors:
Sernova Corp
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, MD
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees
of future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials, and the development of new technologies, cell therapy solutions and or products. The information
disclosed represents results from one patient and may not be representative of all study patients or of the final
study results. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking
statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - May 09, 2022 9 May, 2022
Sernova Announces Abstract on Phase 1/2 Trial with Cell Pouch Selected for Oral Podium Presentation at American Diabetes Association 82nd Scientific Sessions 2022
LONDON, ONTARIO – May 9, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical-stage cell therapy therapeutics company focused on developing a potential ‘functional cure’ for type 1
diabetes (T1D) and other chronic diseases, is pleased to announce that that an abstract has been selected for
an oral podium presentation at the upcoming American Diabetes Association (ADA) 82nd Scientific Sessions, to
be held from June 3-7, 2022, at the Ernest N. Morial Convention Center in New Orleans, LA.
Abstract 306-OR: Modified Approach for Improved Islet Allotransplantation into Prevascularized Sernova Cell
PouchTM Device: Preliminary Results of the Phase I/II Clinical Trial at University of Chicago
Abstract Session: Islet Transplantation —Basic Science
Session Date/Time: Monday, June 6, 2022 at 2:15 PM – 4:15 PM CT
Presentation Time: 3:15-3:30 PM CT
Authors: Bachul PJ, Perez-Guetierrez A, Ling-jia Wang, Golab K, Basto L, Perea L, Tibudan M, Braden J,
Thomas C, Philipson L, Barth R, Fung JJ, Witkowski P
Sernova will disclose additional information about the presentation at the time of the conference in alignment
with the American Diabetes Association’s abstract embargo policies.
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Corporate:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
Media:
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Press Release Communiqué de presse - May 05, 2022 5 May, 2022
Sernova to Participate in Multiple U.S. Healthcare Investor Conferences
Sernova Engages Leading U.S.-Based Healthcare Communications Firm to Broaden Awareness of Potential
‘Functional Cure’ Technology for Type 1 Diabetes
LONDON, ONTARIO – May 5, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical stage regenerative medicine company focused on developing a potential ‘functional cure’ for type 1
diabetes (T1D) and other chronic diseases including hemophilia A and thyroid disease, today announced that
the company will be participating in several upcoming U.S. healthcare industry and investor conferences.
Conference details are provided below.
The Company is also pleased to announce it has engaged New York-based LifeSci Communications, a global
life science and medical technologies-focused communications and marketing agency. LifeSci Communications
will assist Sernova to expand and elevate its profile through strategic communications and public relations.
Sernova is also working with affiliate LifeSci Advisors LLC, a leading investor relations consultancy firm serving
life science companies, providing institutional investor communications and capital markets outreach services
in support of the Company’s U.S. capital markets objectives.
“With multiple collaborations advancing across our pipeline and growing interest in our best-in-class cell
therapy therapeutic solution platform - consisting of immune protected therapeutic cells and our proprietary
Cell Pouch™ medical device - as a potential ‘functional cure’ for multiple patient populations, the timing is right
to drive awareness of our unique cell therapy proposition and unprecedented clinical results including the
demonstration of continuous insulin independence for over two years now in our most advanced Phase 1/2
T1D study patient, in contrast to the clinical setbacks of several of our peer companies,” commented Dr.
Philip Toleikis, President & CEO of Sernova.
UPCOMING U.S. HEALTHCARE INDUSTRY AND INSTITUTIONAL INVESTOR PRESENTATIONS
Event: Roth Capital’s Canada Corporate Access Day
Date: May 17, 2022
Format: Corporate presentation and 1x1 meetings with institutional investors
Location: New York, NY
Event: H.C. Wainwright Global Life Sciences Conference
Date: May 24-25, 2022
Format: Corporate presentation and 1x1 meetings with institutional investors
Location: Miami Beach, FL
Event: Truist Securities Cell Therapy Symposium
Date: June 28, 2022
Format: Panel expert and discussions
Location: New York, NY
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Encouraging interim results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Investors and Analysts
Christopher Barnes Corey Davis, Ph.D.
VP, Investor Relations Managing Director
Sernova Corp. LifeSci Advisors, LLC
christopher.barnes@sernova.com cdavis@lifesciadvisors.com
Tel: 519-902-7923 Tel: 212-915-2577
www.sernova.com
Media
Elizabeth Miller, M.D.
LifeSci Communications
emiller@lifescicomms.com
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to complete collaboration activities; ability to secure collaboration arrangements from its
collaboration activities; ability to execute its business strategy and successfully compete in the market; and
the inherent risks associated with the development of biotechnology combination products generally. Many of
the factors are beyond our control, including those caused by, related to, or impacted by the novel coronavirus
pandemic. Investors should consult the company’s quarterly and annual filings available on www.sedar.com
for additional information on risks and uncertainties relating to the forward-looking statements. Sernova
expressly disclaims any intention or obligation to update or revise any forward-looking statements, whether as
a result of new information, future events or otherwise.
Press Release Communiqué de presse - April 29, 2022 29 April, 2022
Sernova Announces 2022 Annual General Meeting Results
LONDON, ONTARIO – April 29, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE:PSH), a clinical stage
regenerative medicine company focused on developing a potential ‘functional cure’ for type 1 diabetes (T1D)
and other chronic diseases, is pleased to announce results from its Annual General Meeting of Shareholders
(the “AGM”) held virtually via live audio webcast, on April 28, 2022. Shareholders voted overwhelmingly in
favour of all management resolutions proposed in the Company’s Information Circular.
The following resolutions were proposed and approved at the AGM:
• The re-election of the following directors for the ensuing year: Frank Holler, James Parsons, Jeffrey
Bacha, Deborah Brown, Dr. Mohammad Azab and Dr. Philip Toleikis.
• The appointment of Davidson & Company LLP, as auditors of the Company until the next annual meeting
and the authorization of the directors of the Company to fix the remuneration to be paid to the auditors.
“I sincerely appreciate our shareholders ongoing support for Sernova. The Board and management are very
excited about the immediate and long-term prospects of the Company as we expand our therapeutic
applications, broaden our capital markets following and execute on a number of strategic initiatives,” said Dr.
Philip Toleikis, President & CEO of Sernova Corp.
Management’s corporate update to shareholders will be available on Sernova’s website next week at
www.sernova.com.
For further information contact:
Sernova Corp
Christopher Barnes
Tel: (519) 858-5126
christopher.barnes@sernova.com
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
ABOUT SERNOVA
Sernova is developing regenerative medicine therapeutic technologies using a medical device and immune
protected therapeutic cells (i.e., human donor cells, corrected human cells and stem-cell derived cells) to
improve the treatment and quality of life of people with chronic metabolic diseases such as insulin- dependent
diabetes, blood disorders including hemophilia, and other diseases treated through replacement of proteins or
hormones missing or in short supply within the body. For more information, please visit www.sernova.com
ABOUT SERNOVA’S CELL POUCH
The Cell Pouch is a novel, proprietary, scalable, implantable macro-encapsulation device designed for the
long- term survival and function of therapeutic cells. The device is designed to incorporate with tissue, forming
highly vascularized tissue chambers for the transplantation and function of therapeutic cells which then
release proteins and hormones as required to treat disease. The device along with therapeutic cells has been
shown to provide long-term safety and efficacy in small and large animal models of diabetes and has been
proven to provide a biologically compatible environment for insulin-producing cells in humans.
FORWARD-LOOKING INFORMATION
This release may contain forward-looking statements. Forward-looking statements are statements that are not
historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”,
“believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions
“will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in
such forward-looking statements are based on reasonable assumptions, such statements are not guarantees
of future performance, and actual results may differ materially from those in forward-looking statements.
Forward-looking statements are based on the beliefs, estimates, and opinions of Sernova’s management on
the date such statements were made, which include our beliefs about the conduct and outcome of clinical
trials. The information disclosed represents results from one patient and may not be representative of all
study patients or of the final study results. Sernova expressly disclaims any intention or obligation to update or
revise any forward-looking statements whether as a result of new information, future events or otherwise.
Press Release Communiqué de presse - March 17, 2022 17 March, 2022
Data Safety Monitoring Board Recommends Continuation of Phase 1/2 Clinical Trial with Sernova’s Cell Pouch System™ in Patients with Type-1 Diabetes
Confirms Ongoing Safety and Tolerability of Sernova’s Cell Pouch
March 17, 2022 10:00 a.m. EDT
LONDON, ONTARIO – March 17, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that the Data
Safety Monitoring Board ("DSMB") has completed the third annual review of Sernova’s ongoing Phase 1/2
clinical study “Safety, Tolerability and Efficacy Study of Sernova’s Cell Pouch for Clinical Islet Transplantation”
in patients with Type-1 Diabetes (T1D) who suffer from hypoglycemia unawareness and severe hypoglycemic
events.
In their assessment, the DSMB recommended that the clinical study should continue according to the study
plan.
The DSMB is an independent committee of clinical experts who review the accumulated trial data to evaluate
patient safety and ensure the integrity of the study data.
“This recommendation from the DSMB affirms our understanding of the safety of Cell Pouch in this patient
population transplanted with human donor islets. We look forward to sharing updates from the study through
upcoming conference presentations by Dr. Piotr Witkowski, the trial Principal Investigator.” said Dr. Philip
Toleikis, President & CEO of Sernova Corp.
For more information on this clinical trial, please visit www.clinicaltrials.gov/ct2/show/NCT03513939. For
more information on enrollment and recruitment details please visit www.pwitkowski.org/sernova.
ABOUT HYPOGLYCEMIA UNAWARENESS
Hypoglycemia unawareness is a person’s inability to recognize the symptoms of low blood sugar before they
become severe enough to be incapacitating or even fatal, which may occur when blood glucose levels are
below 3.0 mmol/L. It is estimated that approximately 15% of people with T1D, or approximately 240,000
people, are affected by hypoglycemia unawareness in the US alone.
Severe symptoms of low blood sugar include confusion, slurred speech, impaired motor coordination and
personality changes. Individuals experiencing a severe hypoglycemic event can lose their ability for self-care
and self-control, requiring urgent intervention from another person to prevent loss of consciousness, seizure,
coma, or death. After a person has had a first hypoglycemia unawareness episode, more are likely to occur.
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Positive initial results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Press Release Communiqué de presse - February 24, 2022 24 February, 2022
Sernova Corp Ranks Among Top 50 Performing Companies on the 2022 TSX Venture List
Sernova awarded top performer status for two years standing
February 24, 2022 7:30 a.m. EST
LONDON, ONTARIO – February 24, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical-stage regenerative medicine and cell therapy therapeutics company focused on developing a potential
‘functional cure’ for type 1 diabetes (T1D) and other chronic diseases, is pleased to announce that that it has
been named as one of the top 50 performers on the TSX Venture Exchange.
The 2022 TSX Venture Top 50 is a ranking of top performers on the TSX Venture Exchange over the last year
based on three equally weighted criteria: share price appreciation, average trading volume and market
capitalization growth.
“We are honored by the TSX Venture Exchange recognition of Sernova as a 2022 Top 50 recipient company.
Being awarded this title two years in a row is strong validation of our persistent dedication to increasing
shareholder value as we continue to deliver on our strategic plan to build a leadership position in the
regenerative medicine cell therapy therapeutics field. In 2022, we look forward to driving continued success
through, evolving our clinical programs, further developing our pharmaceutical partnerships and by advancing
our capital market initiatives,” said Dr. Philip Toleikis, Chief Executive Officer of Sernova.
As part of the award, the TSX Venture Exchange sponsored a Q&A highlight interview with Dr. Toleikis. To view
the video, please https://share.vidyard.com/watch/dsfSgoQyYi87x8pj8oUEz6
and for the complete list of 2022 TSX Venture 50 companies.
ABOUT SERNOVA
Sernova is developing regenerative medicine therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. The device
upon implantation is designed to incorporate with tissue, forming highly vascularized tissue chambers for the
transplantation and function of therapeutic cells, which then release proteins and hormones as required to
treat disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
I/II study at the University of Chicago. Positive initial results have been presented at several international
scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeSci Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Press Release Communiqué de presse - January 27, 2022 27 January, 2022
Sernova Announces Peer Reviewed Publication Demonstrating Positive Preclinical Safety and Efficacy Indicators of Its Novel Cell Pouch System™ Therapeutic Approach for Treatment of Thyroid Disease
Sernova prepares for clinical trial of new treatment for post-operative hypothyroidism
LONDON, ONTARIO – January 27, 2022 – Sernova Corp. (TSX-V:SVA) (OTCQB:SEOVF) (FSE/XETRA:PSH), a
clinical-stage regenerative medicine and cell therapy therapeutics company developing a potential ‘functional
cure’ for chronic diseases including type 1 diabetes (T1D) is pleased to announce publication of a peer
reviewed preclinical study demonstrating positive results of a novel Cell Pouch System™ cell therapy approach
to treat hypothyroidism and potentially avoid lifelong dependence on thyroid medication following surgical
removal of the thyroid gland.
The journal article entitled “Subcutaneous transplantation of human thyroid tissue into a pre-vascularized Cell
Pouch™ device in a Mus musculus model: Evidence of viability and function for thyroid transplantation,” by
lead author, Dr. Sam M. Wiseman was published in the prestigious scientific journal, PLOS ONE, January 20,
2022. In this study, thyroid tissue from patients undergoing surgery for treatment of benign disease was
transplanted into Sernova Cell Pouches that had been previously implanted into laboratory mice. The aim of
the study was to investigate the long-term survival of human thyroid tissue in the Cell Pouch and evaluate the
ability of these thyroid transplants to release thyroid hormones into the bloodstream. The study confirmed that
the human thyroid tissue transplanted into the Cell Pouch survived and released human thyroglobulin into the
bloodstream, with no adverse effects for the three-months duration of the study. Thyroglobulin was used as a
biomarker efficacy measure in this study as it is the precursor of thyroid hormones.
“I’m very excited about this study because it represents a critical first step towards a future where we can offer
our patients a treatment option that allows for preservation of their thyroid function with avoidance of
postoperative hypothyroidism, its many associated morbidities and life-long dependence on thyroid
medication,” commented Sam M. Wiseman BSc, MD, FRCSC, FACS.
Dr. Philip Toleikis, President and CEO Sernova Corp stated, “For hypothyroid disease, these data support the
potential of our Cell Pouch to allow for a recovery of the natural thyroid hormone feedback system following
thyroidectomy, restoring thyroid hormone levels without the risks and side effects associated with hormone
replacement drugs. This could provide life-changing options for the more than 150,000 patients who undergo
a thyroidectomy in the US, alone, each year. These preclinical data are consistent with our findings utilizing the
Cell Pouch in the treatment of T1D and Hemophilia A. We believe the Sernova Cell Pouch System therapeutic
approach could provide a ‘functional cure’ for millions of patients who suffer from afflictions caused by the
absence of systemic proteins or hormones.”
Sernova Corp., with Dr. Wiseman as clinical investigator, is preparing regulatory documents to proceed with a
Phase 1/2 human clinical trial in subjects undergoing thyroid surgery. In this study, the subjects will be
implanted with the Cell Pouch to create the vascularized tissue environment several weeks prior to transplant
of their healthy thyroid tissue. The objective of the study is to assess the safety and efficacy of the Cell Pouch
transplanted tissue, with efficacy measured as recovery of thyroid hormone in the bloodstream. The Company
expects to submit a clinical trial application within 2022.
The thyroid gland produces hormones that regulate metabolism within a narrow functional range. Thyroid
hormone replacement drugs are frequently used to treat insufficient or absent thyroid activity. Optimization of
thyroid hormone replacement medications can be difficult with dose adjustments requiring frequent lab tests
to reach appropriate levels. Thyroid hormone replacement therapy is associated with several side-effects
including impaired cognition, lethargy, and weight gain, leading to diminished quality of life, and incurring
significant ongoing costs to the patient and healthcare system.
ABOUT THYROID DISEASE
Surgical removal of the thyroid gland, or thyroidectomy, is commonly performed for management of thyroid
cancers, and for treatment of benign (non-cancerous) diseases that include nodules, goitre, and
hyperthyroidism. It is estimated that about 150,000 thyroidectomies are performed in the U.S. annually, with
most individuals undergoing thyroid surgery eventually being diagnosed with benign conditions. Some patients
undergoing partial thyroidectomy and all patients undergoing total thyroidectomy require life-long oral
postoperative thyroid hormone replacement treatment.
ABOUT SERNOVA
Sernova is developing regenerative medicine therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, thyroid disease and other diseases treated
through cellular production of proteins or hormones missing or in short supply within the body. For more
information, please visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. The device
upon implantation is designed to incorporate with tissue, forming highly vascularized tissue chambers for the
transplantation and function of therapeutic cells, which then release proteins and hormones as required to
treat disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans. Sernova is currently conducting a Phase 1/2 study at the University of
Chicago. Positive initial results have been presented at several international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects",
"potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or
"should" occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.
Disclaimer Avis de non-responsabilite
Sernova maintains the investor relations section of this internet site as an informational service and for the readers. Sernova maintient la section des relations investisseurs de ce site Internet en tant que service afin d’informer les lecteurs.
This site is not intended to supplement or substitute for the legal disclosure for the Corporation or the prospectus disclosure related to the public offering of any of its securities. Please read the legal notice on the site before you proceed. Ce site n'a pas pour objet de compléter ou de remplacer la divulgation légale de la Société ou les informations du prospectus relatives à l’offre au public de ses titres. Veuillez lire l'avis juridique sur le site avant de poursuivre.
Privacy PolicyPolitique de confidentialité
Updated July 6, 2018
Please read this Policy carefully along with our Legal Notice that describes our Terms of Use for the Website.
By accessing www.sernova.com (the “Website”) you hereby agree with the practices described in this Privacy Policy (the “Policy”)
This Policy applies to all information gathered through the Website and/or any related marketing technique or events.
Information Collection
The information collected is limited to the information that you decide to share with us through the News Dispatch Service, when participating at event or activities or in the general course of business by expressing an interest in obtaining information about Sernova Corp. and our products, such as name, email, phone number, and similar contact information. This information is stored through MailChimp (please refer to MailChimp Privacy Policy at https://mailchimp.com/legal/privacy/).
Information Sharing
Sernova Corp. is the sole owner of any information collected on the Website. We do not sell, share or rent this information to others.
Traffic and Automatic Information Collection
Sernova Corp. maintains log files of the traffic on www.sernova.com. This information is not linked to any personal information that you have provided us. Logs are used to manage traffic, identify content accessed, and IT requirements. Information logged and automatically collected includes without being limited to IP addresses and browser types. This information does not reveal your specific identity.
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Cookies can be used to provide you with a more personalized experience. The Website may use cookies to make that experience more companionable when you return to the Website. You have the option at all time to decline the use of cookies. If you choose to do so, you may not be able to fully use all features of the Website. You can also delete cookie files at all time from your computer. Those cookies may include first-party cookies (such as the Google Analytics cookies).
Updates
This Policy is a living document and may be amended or updated from time to time without further notice. We encourage you to review the Policy periodically.
Contact
If you have any questions or comments about our policy, you can email us at info@sernova.com or by phone at 1(877) 299-4603 or by mail at
Sernova Corp.
700 Collip Circle, Suite 114
London, ON Canada N6G 4X8
Mis à jour le 6 juillet 2018
Veuillez lire attentivement cette politique ainsi que notre avis juridique qui décrit nos conditions d'utilisation du site Web.
En accédant à www.sernova.com (le «site Web»), vous acceptez les pratiques décrites dans la présente politique de confidentialité (la «politique»).
Cette politique s'applique à toutes les informations collectées via le site Web et / ou toute technique ou événement marketing associé.
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Les informations collectées se limitent aux informations que vous décidez de partager avec nous par le biais du service d’expédition de nouvelles, lorsque vous participez à un événement ou à des activités ou que vous vous intéressez à obtenir des informations sur Sernova Corp. comme nom, email, numéro de téléphone et informations de contact similaires. Ces informations sont stockées via MailChimp (veuillez vous reporter aux règles de confidentialité de MailChimp sur https://mailchimp.com/legal/privacy/).
Partage d'information
Sernova Corp. est l'unique propriétaire de toute information collectée sur le site Web. Nous ne vendons pas, ne partageons pas ou ne louons pas ces informations à des tiers.
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Mises à jour
Cette politique est un document évolutif et peut être modifié ou mis à jour de temps à autre sans préavis. Nous vous encourageons à consulter la politique périodiquement.
Contact
Si vous avez des questions ou des commentaires sur notre politique, vous pouvez nous envoyer un courriel à info@sernova.com ou par téléphone au 1 (877) 299-4603 ou par courrier à
Sernova Corp.
700 Collip Circle, Suite 114
London, ON Canada N6G 4X8